Multivariable analyses for PFS2
| Clinical parameter | Univariate cox regression | Multivariate cox regression | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | EXP (B, 95% CI) | P-value | |
| Gender (male vs. female) | 0.44 (0.13–0.87) | 0.0248 | 2.56 (1.08–6.07) | 0.0340 |
| PS-ECOG (≥ 2 vs. < 2) | 1.57 (0. 60–5.06) | 0.3039 | ||
| Age (≥ 70 vs. < 70) | 1.80 (0.87–3.54) | 0.1157 | ||
| Histotype (squamous vs. non-squamous) | 1.56 (0.79–3.29) | 0.1938 | ||
| Smoke (yes vs. no) | 0.95 (0.22–4.14) | 0.9545 | ||
| BM (no vs. yes) | 2.60 (1.47–7.23) | 0.0037 | 0.38 (0.15–0.42) | 0.0340 |
| Pulmonary metastases (no vs. yes) | 1.71 (0.29–1.87) | 0.5209 | ||
| Liver metastases (no vs. yes) | 0.55 (0.15–1.41) | 0.1756 | ||
| Cerebral metastases (no vs. yes) | 0.50 (0.09–1.55) | 0.1769 | ||
| Adrenal metastases (no vs. yes) | 1.52 (0.62–3.40) | 0.3830 | ||
| Lymph nodes metastases (no vs. yes) | 1.00 (0.43–2.33) | 0.9996 | ||
| Pleural metastases (no vs. yes) | 0.85 (0.41–1.77) | 0.6585 | ||
| Maximum lesion diameter (cut-off = 6.3 cm) | 0.74 (0.34–1.64) | 0.4687 | ||
| Sum of the 5 major lesions diameters (cut-off = 14.3 cm) | 0.66 (0.29–1.66) | 0.4071 | ||
| Intrathoracic vs. extrathoracic disease | 0.71 (0.33–1.46) | 0.3333 | ||
| Measurable vs. not-measurable disease | 0.40 (0.21–0.87) | 0.0199 | 0.58 (0.22–1.54) | 0.2808 |
| Number of metastatic sites (≥ 4 vs. < 4) | 0.40 (0.20–0.97) | 0.4231 | ||