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Exploration of Targeted Anti-tumor Therapy
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T1
From:
Targeting cytoskeletal phosphorylation in cancer
Table 1.
Main human β-actin phosphorylation sites
Gene
Site
Putative kinase
Discovered by/inhibitor
Effect
References
ACTB
Ser33
PLK1
BI_4834
Probably mitosis
[
12
]
Tyr53
Src
Biochemical assays, targeted mutation
MF disassembly
[
16
,
17
]
Tyr91
EGFR
erlotinib
not known
[
27
]
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EGFR: epidermal growth factor receptor; Tyr: Tyrosine