Main human vimentin phosphorylation sites
| Gene | Site | Putative kinase | Discovered by/inhibitor | Effect | Reference |
|---|---|---|---|---|---|
| VIM | Ser5/7/8/9/10 | PKCα | Calyculin A (phosphatase) | Cell polarity | [63] |
| Ser26/51/66 | PAK1 | Biochemical assays, selumetinib, vemurafenib | Abnormal assembly | [113, 114] | |
| Ser39 | AKT/PKB | A-674563 | Proteolytic protection, slowed polymerization? | [69] | |
| Ser56 | AKT/PKBROCK | A-674563siRNA | Filament disassembly | [69][72] | |
| Ser72 | ROCK1 | Targeted mutation, Y27632 | Increased cell migration | [75, 76, 115] | |
| Ser73 | AURKB | Biochemical assays | Mitosis? | [114, 116] | |
| Ser83 | PLK-1, CaMKII | Biochemical assays, KN-93 (CaMKII inhibitor) | Filament disassembly and pathogen interaction | [77, 117, 118] |
CaMKII: calmodulin-dependent protein kinase II