Temperature fit parameters of the ADCs
| ADCs | TmPeak-1 | TmPeak-2 | TmPeak-3 | TmPeak-4 |
|---|---|---|---|---|
| Trastuzumab | 64.8°C | 79.1°C | ||
| T-DM1 | 62.5°C | 74.8°C | 78.9°C | |
| Trastuzumab-MCC-maytansinoid (DAR = 4.1) | 63.8°C | 73.0°C | 78.0°C | |
| Trastuzumab-MC-VC-PAB-MMAE (DAR = 2.0) | 63.5°C | 75.1°C | 79.2°C | |
| Trastuzumab-MC-VC-PAB-MMAE (DAR = 4.0) | 54.6°C | 62.0°C | 73.4°C | 78.0°C |