An overview of proteins that have been shown to modulate Bax-induced cell death in yeast
| Function | Activation: overexpression stimulates Bax effects and/or deletion inhibits Bax effects | Inhibition: overexpression inhibits Bax effects and/or deletion stimulates Bax effects | |||
|---|---|---|---|---|---|
| Mammalian proteins | Yeast proteins | Mammalian proteins | Yeast proteins | Plant and viral proteins | |
| Bcl-2 family and related | tBid [171, 172]Puma [173]Noxa, Bik [174] | Bcl-2, Bcl-xL [22, 39, 44, 46, 175]Bfl-1/A1 [176] | see below for Ybh3 | M11 [177]DPV022 [178] | |
| Bax-inhibitor | BI-1 [50] | BI-1/Bxi1/Ybh3 [59] (not tested with Bax in [89, 90]) | BI-1 [59, 61, 179, 180] | ||
| Traffic | Tom22 [135, 137] | Tom22 [135, 139]TOM complex [136]Mdm34 [148] | Vps34 [54] Vamp3 [181] | Sec22 [182] | AtVAMP [63] |
| Autophagy and protein quality control | Uth1 [73, 183]Yme1 [184] Naa20 [185] | Atg5, Atg7 [73] | Sentrin [186] | ||
| Protein aggregates | PrP [187,188]α-synuclein [189] | ||||
| Protein- kinases | AKT [128]PKCα [190] | AKT [128] | Sch9 [191] | ||
| Stress responses | Hsp60 [192]Hog1 [193] | Trx1 [194]Fth1 [195] | Tsa1 [194]Rgi1 [195] | tQM [196]LePHGPx [64] AtEBP [62, 65] BI-GST [60, 197]sAPX [198] | |
| Energetic metabolism | Qcr7, Cyc3, Cox4, Cox7, Atp4, Pet9 [161, 199]Data not confirmed in [155] | COX6A1 [200] | OYE2 [69, 201]Por1 [199] | GAPDH [202] | |
| Lipid metabolism | SMS1 [203] | Hfd1 [184]Fah1 [204] | fah1, fah2 [204]BcLCB(2) [205] | ||
| Others | hRPL9 [206]Septin7 [70]Tsc22 [55] | Cdc10 [70] | Omp2b [67] | ||