Exploration of Targeted Anti-tumor Therapy

Table 1. Bevacizumab and erlotinib in EGFR wild type NSCLC patients

Author	Phase	Line of treatment	Pts	Treatment	Response rate(%)	Progression-free survival (months)	Overall survival (months)
Herbst et al. [17]	I/II	Second line	40	Erlotinib + Bevacizumab	20 95% CI: 7.6-32.4%	7.0; 1-year PFS = 38.0%, 95% CI: 24.3-59.6%	12.6; 1-year OS = 54.2%, 95% CI: 40.0%-73.4%
Herbst et al. [18]	II	Second line	120	Bevacizumab + CT* vs. bevacizumab + erlotinib vs. CT*	12.5 vs. 17.9 vs. 12.2	4.8 vs. 4.4 vs. 3.0 HR: 0.66, 95% CI: 0.38-1.16 HR: 0.72, 95% CI: 0.42-1.23	12.6 vs. 13.7 vs. 8.6 HR: 0.71, 95% CI: 0.41-1.21 HR: 0.78, 95% CI: 0.46-1.31
Herbst et al. BeTa trial [19]	III	Second line	636	Erlotinib + Bevacizumab vs. Erlotinib + placebo	14 vs. 7	3.4 vs.1.7 HR: 0.62, 95% CI: 0.52-0.75	9.3 vs. 9.2 HR: 0.97, 95% CI: 0.80-1.18, P = 0.7583
Wang et al. [20]	III	Second line	297	Erlotinib + Bevacizumab + Panitumumab vs. Erlotinib + placebo	38 vs.15 P = 0.014	4.6 vs. 1.9 P = 0.003	10.4 vs. 8.9 P = 0.031
Besse et al. BRAIN trial [21]	II	Second line	24	Erlotinib + Bevacizumab	12.5 95% CI: 2.7-32.4	6.3 95% CI: 3.0-8.4	12.0 95% CI: 8.9-20.2
Johnson et al. ATLAS trial [22]	III	Maintenance after I line	745	Erlotinib + Bevacizumab vs. Bevacizumab alone	-	4.8 vs. 3.7, HR: 0.71, 95% CI: 0.58-0.86 P < 0.001	14.4 vs. 13.3 HR: 0.92, 95% CI: 0.7-1.21 P = 0.5341
Dingemans et al. [23]	II	First line	47	Erlotinib + Bevacizumab	25	3.8 (95% CI: 2.3-5.4)	6.9 (95% CI: I 5.5-8.4)
Zappa et al. trial SAKK 19/05 [24]	II	First line	101	Erlotinib + Bevacizumab	17.8	4.1 (95% CI: 2.9-5.5)	14.1 (95% CI: 10.7-19.0)
Ciuleanu et al. TASK trial [25]	II	First line	200	Erlotinib + Bevacizumab vs. Chemo + Bevacizumab	23.8 vs. 34.4, P = 0.19	18.4 vs. 25 weeks HR 2.05, 95% CI: 1.11-3.77	16.4 vs. n.r HR:1.24, 95% CI: 0.75-2.05
Thomas et al. INNOVATIONS [26]	II	First line	224	Erlotinib + Bevacizumab vs. Cisplatin + Gemcitabine + Bevacizumab	12 vs. 36, P < 0.0001	3.5 vs. 6.9 HR: 1.85; 95% CI:1.39-2.45 P < 0.0001	12.6 vs.17.8 HR: 1.41; 95% CI: 1.01-1.97 P = 0.04

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Docetaxel or erlotinib; n.r: not reached

Declarations

Author contributions

GP and AM conceived the paper and prepared the majority of the first draft, while the other authors contributed further sections. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

AM declares the following speakers’ bureau: Roche, Takeda, Pfizer, Boehringer Ingelheim, AstraZeneca, MSD Oncology, BMS. The other authors declare that no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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