Exploration of Targeted Anti-tumor Therapy

Table 2. Oral VEGFR inhibitors and erlotinib in EGFR wild type NSCLC patients

Author	Phase	Line of Treatment	Patients	Treatment	Response rate (%)	Progression-free survival (months)	Overall survival (months)
Spigel et al. [29]	II	Second line	168	Sorafenib + erlotinib vs. placebo + erlotinib	8 vs. 11, P = 0.555	3.38 vs. 1.94, HR: 0.86; 95% CI: 0.60-1.22 P = 0.196	7.62 vs. 7.23, HR: 0.89; 95% CI: 0.59-1.34 P = 0.290
Scagliotti et al. [32]	III	Second line	960	Sunitinib + erlotinib vs. placebo + erlotinib	10.6 vs. 6.9, P = 0.0471	3.6 vs. 2.0 HR: 0.807; 95% CI: 0.695-0.937 P = 0.0023	9.0 vs. 8.5, HR: 0.922; 95% CI: 0.797-1.067 P = 0.1388
Groen et al. [33]	II	Second line	132	Sunitinib + erlotinib vs. placebo + erlotinib	4.6 vs. 3.0, P = 0.624	2.8 vs. 2.0 HR: 0.898; 80% CI: 0.671-1.203 P = 0.321	8.2 vs. 7.6 HR: 1.066; 95% CI: 0.705-1.612 P = 0.617

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Author contributions

GP and AM conceived the paper and prepared the majority of the first draft, while the other authors contributed further sections. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

AM declares the following speakers’ bureau: Roche, Takeda, Pfizer, Boehringer Ingelheim, AstraZeneca, MSD Oncology, BMS. The other authors declare that no conflicts of interest.

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Not applicable.

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