Exploration of Targeted Anti-tumor Therapy

Table 4. Ongoing studies

Trial	Phase	Setting	Stage	Patients	Treatment	Primary end points
Beverly trial NCT02633189	III	Metastatic, first line	IV stage	200	Erlotinib + Bevacizumab vs. Erlotinib	PFS
Brilliant trial NCT02655536	II	Metastatic, first line	IV stage, brain metastases	109	Erlotinib + Bevacizumab vs. Erlotinib	PFS
Ava-Ta trial NCT03126799	II	Metastatic, first line	IV stage	128	Erlotinib + Bevacizumab vs. Bevacizumab	PFS
NCT02803203	I/II	Metastatic, first line	IV stage	50	Osimertinib + Bevacizumab	PFS
BOOSTER NCT03133546	II	Metastatic, second line	IV stage, T790M mutated	155	Osimertinib + Bevacizumab vs. Osimertinib	PFS
ACCRU NCT02971501	II	Metastatic, first line	IV stage, brain metastases	112	Osimertinib + Bevacizumab vs. Osimertinib	PFS
OWONBNSCLCLM NCT04148898	II	Metastatic, first line	IV stage, leptomeningeal metastases	80	Osimertinib + Bevacizumab vs. Osimertinib	ORR and iPFS
NCT04181060	III	Metastatic, first line	IV stage	300	Osimertinib + Bevacizumab vs. Osimertininib	PFS
NCT03909334	II	Metastatic, first line	IV stage, also in patients with brain metastases	150	Osimertinib + Ramucirumab vs. Osimertinib	PFS
NCT02789345	I	Metastatic, first line	IV stage, T790M mutated	74	Osimertinib + Ramucirumab + Necitumumab	DLTs

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iPFS: intracranial progression-free survival

Declarations

Author contributions

GP and AM conceived the paper and prepared the majority of the first draft, while the other authors contributed further sections. All authors contributed to manuscript revision, read and approved the submitted version.

Conflicts of interest

AM declares the following speakers’ bureau: Roche, Takeda, Pfizer, Boehringer Ingelheim, AstraZeneca, MSD Oncology, BMS. The other authors declare that no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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