List of select pan-Bcl-2 or Mcl-1 specific inhibitors
| Compound | Target proteins | References |
|---|---|---|
| Compounds that down regulate Mcl-1 expression | ||
| Flavopiridol | CDK | [93, 94] |
| Seliciclib | CDK | [95, 96] |
| Sorafenib | Kinases | [108] |
| Resveratrol | STAT transcription factors | [98] |
| BH3 mimetics | ||
| Pan-Bcl-2 inhibitors | ||
| GX15-070 (obatoclax) | Bcl-2, Mcl-1, Bcl-xl, Bcl-w, Bcl-B | [119–121] |
| Gossypol (AT-101) | Bcl-2, Mcl-1, Bcl-xl | [122, 123, 140] |
| BI-97C1 (sabutoclax) | Bcl-2, Mcl-1, Bcl-xl, Bfl-1 | [88, 116, 118] |
| TW-37 | Bcl-2, Mcl-1, Bcl-xl | [7, 110, 111] |
| Mcl-1-specific inhibitors | ||
| MIM1 | Mcl-1 | [110, 112, 113] |
| Maritoclax (marinopyrrole A) | Mcl-1 | [68, 123, 126] |
| UMI-77 | Mcl-1 | [51, 127, 128] |
| AZD5991 | Mcl-1 | [17] |
| S63845 | Mcl-1 | [76] |
| AMG-176 | Mcl-1 | [66, 130, 131] |
| AMG-397 | Mcl-1 | [132] |