Bile-based liquid biopsy in BTCs
| Authors | Number of patients | Type of analysis on bile cfDNA | Relevance | References |
|---|---|---|---|---|
| Shen et al. | 10 | Targeted deep sequencing | Bile-based liquid biopsy features high concordance with blood samples and tumor tissue | [45] |
| Gou et al. | 28 | qPCR | Bile-based liquid biopsy features high concordance with blood samples and tumor tissue | [46] |
| Driescher et al. | 35 | NGS (qPCR for KRAS analysis) | Bile-based liquid biopsy features high concordance with blood samples and tumor tissue and can outperform blood-based biopsy | [47] |
| Han et al. | 42 | qPCR | Detection of KRAS mutations in bile samples predicts poorer prognosis | [48] |