From:  Roles of calcium signaling in cancer metastasis to bone

TRP channels and their functions in different cancers

FamilyMembersCancer typeEffectsReferences
TRPCTRPC1Colorectal cancer (CRC)Enhanced cell proliferation, migration, invasion, and metastasis and apoptosis resistance[32, 33]
TRPC3Gastric cancerTumorigenesis[34]
Breast cancerEnhanced proliferation and apoptosis resistance[35]
TRPC5CRCReduction in cancer differentiation[36]
Breast cancerChemotherapeutic resistance[37]
TRPC6Hepatocellular carcinomaEnhanced migration and invasion[38]
Breast cancerProliferation, migration, and invasion[39]
Oesophageal cancerEssential for G2 phase progression[40]
TRPVTRPV2Gastric cancerGastric cancer[41]
TRPV4Gastric cancerEnhanced proliferation, migration, and invasion[42]
TRPV6Breast cancerTumor metastasis[43]
TRPMTRPM3Clear cell renal cell carcinoma (RCC)Tumor growth[44]
TRPM4Prostate cancerEnhanced proliferation[45]
TRPM7Ovarian cancerEMT and enhanced proliferation[46, 47]
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TRPC: TRP canonical