Factors influencing IGF-1 and GH concentrations [2]
| ↑ IGF-1 | ↓ IGF-1 | ↑ GH | ↓ GH |
|---|---|---|---|
| Oral contraceptives with estrogens or selective estrogen receptor modulators | Anorexia and malnutrition | Oral contraceptives with estrogens or selective estrogen receptor modulators | Late puberty |
| Use of testosterone | Renal and liver failure | Use of testosterone | Age > 60 years |
| Pregnancy | Poorly controlled diabetes | Pregnancy | Severe obesity |
| Severe obesity | Severe illness (e.g., sepsis or multiorgan failure) | Anorexia and malnutrition | |
| Late puberty | Renal and liver failure | ||
| Age > 60 years | Poorly controlled diabetes | ||
| Severe obesity | Severe illness (e.g., sepsis or multiorgan failure) | ||
| Severe obesity |