From:  Patient diagnosed with acromegaly and pituitary apoplexy after breast carcinoma treatment: challenges in diagnosis and management

Predictors of response to first-generation somatostatin analogues

ParametersHigher responseLower responseRef.
E-cadherin↑↓[31]
Ki67↓↑[38–40]
AgeOlder ageYounger age[30, 41–44]
SexFemaleMale[45–47]
Baseline GH and IGF-1Moderately elevated levelsHigh levels[45]
T2 signal on MRIHypointensityHyperintensity[37]
Tumor volume and invasion↓↑[41]
Response to the short octreotideYes response (GH nadir < 3.5 ng/mL)No response (GH nadir > 7 ng/mL)[17]
Cytokeratin distribution patternPerinuclear distribution (densely granular)Distribution in droplet; fibrous bodies > 70% (sparsely granulated)[38]
SSTR-2 expression and SSTR-2/SSTR-5 ratio↑↓[25]
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STTR: somatostatin receptor; AIP: aryl hydrocarbon receptor-interacting protein