Weight loss interventions and circulating eCB levels
| eCB | Lifestyle changes | Bariatric surgery | ||||
|---|---|---|---|---|---|---|
| PA | HD | PA + HD | LSG | RYGB | BPD | |
| AEA | ↑ [76–80, 82, 83, 86, 90]↓ [84, 85] | ↓ [92, 94]Ø [93] | ↑ [97]↓ [69, 97]Ø [96] | ↓ [70, 98, 99] | ↑ [100]↓ [99]Ø [101] | ↓ [98] |
| 2-AG | ↑ [77, 81–83, 90]↓ [84] | Ø [92, 93] | ↓ [69, 96, 97] | ↑ [99]↓ [70]Ø [98] | ↑ [99]↓ [101]Ø [100] | Ø [98] |
↑: increase; ↓: decrease; Ø: no change. eCB: endocannabinoid; PA: physical activity; HD: hypocaloric diet; LSG: laparoscopic sleeve gastrectomy; RYGB: Roux-en-Y gastric bypass; BPD: biliopancreatic diversion; AEA: N-arachidonoyl-ethanolamine; 2-AG: 2-arachidonoyl-glycerol