Studies comparing aggressive hydration with lactate Ringer plus indomethacin: intra-procedural risk factors
| Author (country, year) [ref] | Difficult cannulation | Pancreatic duct cannulation | Pancreatic duct injection | Precut | Pancreatic sphincterotomy | Balloon dilation papilla | Trainee involved |
|---|---|---|---|---|---|---|---|
| Mok et al. (USA, 2017) [47] | > 8 attempts13% LR + indomethacin13% NSS + placebo17% NSS + indomethacin10% LR + placebo(p = 0.87) | NA | 21% LR + indomethacin31% NSS + placebo25% NSS + indomethacin31% LR + placebo(p = 0.59) | 0% LR + indomethacin2% NSS + placebo0% NSS + indomethacin2% LR + placebo(p = 1.00) | 4% LR + indomethacin10% NSS + placebo13% NSS + indomethacin8% LR + placebo(p = 0.59) | 21% LR + indomethacin21% NSS + placebo19% NSS + indomethacin23% LR + placebo(p = 0.74) | 100% |
| Hajalikhani et al. (Iran, 2018) [48] | NA | 8.4% vs. 8%(p = 0.99) | NA | 21.5% vs. 21.4%(p = 0.99) | 6.5% vs. 7.1%(p = 0.99) | 42.1% vs. 33.9%(p = 0.26) | NA |
| Thanage et al. (India, 2021) [49] | > 8 attempts43.8% LR + diclofenac64.9% LR56.1% diclofenac(p = 0.88) | 10.5% LR + diclofenac7% LR3.5% diclofenac(p = 0.34) | NA | 26.3% LR + diclofenac5.2% LR22.8% diclofenac(p = 0.007) | NA | NA | NA |
| Boal Carvalho et al. (Portugal, 2022) [50] | NA | 13.3% vs. 13.9%(p = ns) | 8.4% vs. 8.3%(p = ns) | 7.3% vs. 9.7%(p = ns) | NA | 21.7% vs. 19.4%(p = ns) | NA |
| Sperna Weiland et al. (Netherlands, 2021) [51] | > 5 attempts30% LR + diclofenac29% control(p = 0.96) | 41% LR + diclofenac37% control(p = 0.37) | 15% LR + diclofenac17% control(p = 0.71) | 18% LR + diclofenac13% control(p = 0.06) | < 1% LR + diclofenac< 1% control(p = 0.63) | 5% LR + diclofenac7% control(p = 0.41) | 9% LR + diclofenac8% control(p = 0.89) |
LR: lactated Ringer’s; NA: not available; NSS: normal saline solution