Exploration of Foods and Foodomics

Application	Rationale	References
Cardiometabolic	Mixed effects on low-density lipoprotein cholesterol concentrations with some studies showing an increase. No clear evidence for advantages regarding effects on other cardiometabolic risk markers. May at the initiation of the diet (only) decrease blood pressure, triglyceride, and glycosylated haemoglobin concentration whilst increasing high-density lipoprotein.	[35, 74, 75]
Diabetes type 2	Reduction in the use of medication in type 2 diabetes management.	[75]
Epilepsy	Manages epileptic seizures.	[76]
The low sugar high-fat diet alters synaptic neuronal excitability and neuro protection reducing trigger seizures.	[60, 77–79]
Sport and endurance	Forces the body to use fat as a fuel source, which is more readily stored in larger depots than glycogen.	[19, 80–83]
Weight loss	May at the initiation of the diet (only) support weight loss. Not superior to other diets.	[20–22, 35, 74, 75, 80, 84]

Application

Rationale

References

Cardiometabolic

Mixed effects on low-density lipoprotein cholesterol concentrations with some studies showing an increase. No clear evidence for advantages regarding effects on other cardiometabolic risk markers. May at the initiation of the diet (only) decrease blood pressure, triglyceride, and glycosylated haemoglobin concentration whilst increasing high-density lipoprotein.

[35, 74, 75]

Diabetes type 2

Reduction in the use of medication in type 2 diabetes management.

[75]

Epilepsy

Manages epileptic seizures.

[76]

The low sugar high-fat diet alters synaptic neuronal excitability and neuro protection reducing trigger seizures.

[60, 77–79]

Sport and endurance

Forces the body to use fat as a fuel source, which is more readily stored in larger depots than glycogen.

[19, 80–83]

Weight loss

May at the initiation of the diet (only) support weight loss. Not superior to other diets.

[20–22, 35, 74, 75, 80, 84]