Natural-based biomaterials have gained significant attention from researchers and clinicians for therapeutic applications due to their bioactivity and biocompatibility. Various proteins, polysaccharides, and ceramic materials from seaweed, plants, and crustaceans have been extensively studied for tissue engineering, drug delivery, and biosensor applications. Bone graft substitutes, cardiac stents, and skin graft materials from natural substances are translated into clinical practice and commercialized. We wish to highlight recent and advanced technologies in natural-based biomaterials for clinical applications in this special issue. The special issue will cover various materials and applications, including: alginate, carrageenan, cellulose, collagen, chitosan, fucoidan, gelatin, hydroxyapatite, ulvan, silk fibroin, tissue engineering, drug delivery, biosensor.

Keywords: Antimicrobials, biosensors, cancer, drug delivery, tissue engineering