About the Special Issue

The drug approval process is costly and complex, often taking over a decade due to the rigorous clinical trials and assessments for efficacy and safety. Drug repurposing is a strategy to identify new therapeutic applications for approved or investigational drugs that are outside the range of the original medical indication, offering a cost-effective, time-efficient and highly successful alternative to traditional de novo drug discovery. With the growing need for accessible therapies, drug repurposing has emerged as a powerful and transformative strategy in modern drug development, particularly in cancer therapeutic discoveries. By leveraging existing clinical data and known safety parameters, this approach enables accelerated translation of therapeutic candidates into clinical practice while maintaining rigorous scientific validation standards. Such strategic advantages have attracted considerable attention from researchers and pharmaceutical industries worldwide.

This special issue aims to highlight cutting-edge advances, methodologies, mechanistic discoveries and clinical applications in drug repurposing for cancer therapy. We sincerely invite submissions of high-quality research or review papers on innovative approaches and significant findings in this rapidly evolving field. Topics of interest include, but are not necessarily limited to, computational strategies for systematic drug repositioning, mechanistic insights into off-target effects, clinical trials and case studies in drug repurposing for cancer therapy, with the goal of fostering knowledge exchange and promoting further advancements in drug repurposing for cancer therapy.

Call for Papers