Contents
Special Issue Topic

Exploring Potential Drugs from Natural Products

Guest Editor

Prof. Juergen Reichardt E-Mail

Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, Smithfield QLD, Australia

Research Keywords: human genetics; human genomics; biochemistry; pharmacogenetics; molecular biology

About the Special lssue

Biodiversity is under threat worldwide which may well rob humankind if not all life forms of a valuable asset. This applies universally from subsistence farming to recreation but also specifically to the potential drugs residing unexplored in natural products on land, in the seas and in the air. This special issue will address such undiscovered compounds, strategies to identify them and to uncover potential targets, mechanisms of action and therapeutic uses.

Particular areas of interest include organic chemistry, biochemistry, mechanisms of action and more of potential drugs from natural products. Other foci of interest include strategies for the identification of relevant compounds, drug targets and mechanisms of action of potential drugs derived from natural products as well as the structures, biosynthesis, metabolism etc. of these chemicals.

Keywords: natural products; biochemistry; biosynthesis; metabolism; potential drugs; drug targets Drug discovery

Published Articles

Open Access Review
Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach
Traditional medicines and their active ingredients and some natural products and derived analogs have been used for treating multiple diseases including cancer. Among these compounds cytotoxic agent
Published: July 30, 2024 Explor Drug Sci. 2024;2:408–427
2412 60 1
Open Access Review
Harnessing the immunomodulatory potential of natural products in precision medicine—a comprehensive review
Traditional medicine systems worldwide utilize natural products (NPs), including plant-derived compounds, minerals, and organisms, harnessing their healing potential. NPs offer a rich source of pote
Published: June 27, 2024 Explor Drug Sci. 2024;2:339–360
2354 54 3
Open Access Mini Review
Mini-review on the antimicrobial potential of actinobacteria associated with seagrasses
The search for novel therapeutic agents to combat the crisis of antimicrobial resistance has spanned from terrestrial to unique, marine environments. Currently, most of the drugs available for usage
Published: February 29, 2024 Explor Drug Sci. 2024;2:117–125
1890 53 4
Open Access Review
Phytochemicals for mitigating the COVID-19 crisis: evidence from pre-clinical and clinical studies
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in December 2019 quickly escalated to pandemic levels and had a severe impact on public health. There are 761 m
Published: October 24, 2023 Explor Drug Sci. 2023;1:336–376
3440 85 6
Open Access Review
Natural compounds from medicinal plants against COVID-19
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), known to cause the coronavirus disease 2019 (COVID-19), was declared a pandemic in early 2020. During the past time, several infecti
Published: August 28, 2023 Explor Drug Sci. 2023;1:253–275
2738 81 1
Open Access Review
Approved antibacterial drugs in the last 10 years: from the bench to the clinic
Bacterial infections constitute one of the major cases of primary medical incidences worldwide. Historically, the fight against bacterial infections in humans has been an ongoing battle, due to the
Published: June 30, 2023 Explor Drug Sci. 2023;1:180–209
9810 280 5
Open Access Original Article
Identification of an inter-cysteine loop potentially involved in the activity of Opisthorchis viverrini-granulin-1
Aim: Identification of small bioactive regions in proteins and peptides can be useful information in drug design studies. The current study has shown that an inter-cysteine loop of the N-terminal
Published: June 30, 2023 Explor Drug Sci. 2023;1:172–179
1393 17 0
Open Access Review
Nature-inspired and medicinally relevant short peptides
Peptides constitute an important component of Nature’s pharmacy and they play a significant role in several signaling pathways acting as natural biological messengers. While nature has mastered th
Published: June 27, 2023 Explor Drug Sci. 2023;1:140–171
7810 275 7
Open Access Original Article
Levistolide A and periplogenin inhibit the growth of gastric cancer cells in vitro and in vivo
Aim: In the present study, the natural products levistolide A (LA) and periplogenin (PPG) were studied for their growth inhibitory effects on the development of gastric cancer cells in vitro and,
Published: March 30, 2023 Explor Drug Sci. 2023;1:64–76
1870 32 0