In recent decades, much evidence has shown that a balanced diet rich in a variety of macro- and micronutrients helps to maintain a healthy immune system. In fact, sufficient amounts of minerals such as zinc and magnesium, micronutrients, herbs, and vitamin-rich foods can help the immune system function not only to prevent infections but also to respond more effectively to many pathological conditions such as hypersensitivity and autoimmune diseases. Nutritional status is closely linked to metabolic health status. Metabolic imbalances can induce alterations in immune function due to defective antioxidant mechanisms and microbiota disturbances.

This issue aims to provide a comprehensive view of the scientific literature on a well-balanced diet in supporting optimal immune function by highlighting the importance of nutrients known for their potential to improve the functionality of various components of the immune system. Preclinical, clinical, meta-analysis studies, and analytical reviews will help to deepen the understanding of the molecular mechanisms used by minerals, vitamins, micronutrients, polyphenols, etc., through which nutrition can affect the immune response and its role in preventing numerous immunopathologies.

Keywords: Nutritional influence, immune functionality, immune system