Contents
Special Issue Topic

Bioactive Molecules from Natural Sources

Submission Deadline: August 31, 2025

Guest Editor

Prof. Michio Kurosu E-Mail

Professor, College of Pharmacy, University of Tennessee Health Science Center, USA

About the Special lssue

Natural products constitute an important source for drug discovery to improve human health. At the present time, novel structures of natural products are difficult to isolate from specimens grown under normal conditions. Taking advantage of the genomic, metabolomic, and proteomic databases, the new natural product sciences emerged in the late 20th century. These efforts have resulted in finding novel bioactive natural products. In parallel, robust assay methods to screen natural product libraries and structure-based drug design has proven to be progressable tactics in modern drug discovery programs. The aim of this special issue seeks original research articles and reviews on bioactive natural products, natural product-based medicinal chemistry, chemical syntheses of bioactive natural products, new assay methods to screen natural products, computational chemistry to improve efficacy of natural products, pharmacokinetic and dynamic aspects of drugs of natural product origin, and new strategy to use approved natural product derivatives.

Keywords: Bioactive natural products, assay-guided isolations, genome mining, synthesis, medicinal chemistry, biosynthesis, proteomics, drug targets

Published Articles

Open Access Review
Natural pentafuranosylnucleos(t)ides and their analogs: structure, functions, synthesis, and perspective of medical application
Dmitrii Platov ... Mikhail Drenichev
Published: May 29, 2025 Explor Drug Sci. 2025;3:1008112
401 23 0
Open Access Original Article
Revolutionizing diabetes treatment: computational insights into 4-hydroxy isoleucine derivatives and advanced molecular screening for antidiabetic compounds
Lakshmi Mounika Kelam ... M. Elizabeth Sobhia
Published: April 10, 2025 Explor Drug Sci. 2025;3:1008104
450 14 0