Rationale

Building on the success of the previous special issue on Epilepsy, this new collection aims to capture recent advancements and emerging research in the field. Epilepsy remains a significant global health concern, affecting millions of individuals and necessitating a multidisciplinary approach to address its challenges. New discoveries in molecular mechanisms, therapeutic interventions, and technological innovations continue to shape the future of epilepsy research.

Scope and Focus Areas

This special issue will include papers focusing on but not limited to the following themes:

1. Molecular Mechanisms

o Advances in the understanding of genetic contributions (e.g., SLC12A5/KCC2 mutations).

o Role of ion channels, neurotransmitter systems, and intracellular signaling pathways.

o Insights into neuroinflammation and oxidative stress in epilepsy pathogenesis.

2. Therapeutic Innovations

o Development of new anti-seizure medications and therapeutic targets.

o Dietary interventions such as the ketogenic diet and its variants.

o Cutting-edge surgical techniques and neuromodulation strategies.

3. Technological and Computational Approaches

o Integration of computational models for seizure prediction.

o Application of AI in diagnosis and treatment personalization.

o Development of wearable devices and patient-specific management systems.

4. Psychosocial and Epidemiological Insights

o Long-term impact of social support and stigma reduction.

o Addressing disparities in epilepsy care across different regions.

o Understanding epilepsy’s comorbidities and their management.

Objective

This special issue seeks to foster dialogue and collaboration among researchers, clinicians, and policymakers, paving the way for transformative advances in epilepsy research and care.

Keywords: Epilepsy, disease mechanisms, new therapeutic targets, novel treatment strategies, drug development