In recent decades, the therapeutic approach towards severe allergic and immunological diseases has changed a lot. The previous vision of treating all patients with a single molecule has been modified, giving more and more space to a precision medicine approach. To do this, the concept of phenotype and endotype has been developed in order to identify clinical characteristics and molecular mechanisms that do not work properly, in order to act in a tailor-made way on them. 

The therapeutic response to these needs has been the “biological drugs”, which have radically changed the approach towards many diseases, ensuring a better quality of life for patients. 

This Special Issue will deal with various aspects related to the application of biological drugs in a vast number of allergo-immunological pathologies in which they are currently used.

Keywords: Biological drugs, precision medicine, new therapeutical approach