Atopic dermatitis (AD), also known as eczema, is a chronic inflammatory skin condition that often appears as red, itchy rashes. Its exact cause isn’t fully understood, but it's believed to involve a combination of genetic, environmental, and immune system factors. People with AD often have a compromised skin barrier, which allows moisture to escape and irritants or allergens to enter, leading to dryness and inflammation. Similarly, an overactive immune response plays a role in the inflammation and itching associated with AD. Certain immune cells release chemicals that cause skin irritation and itching. In addition, mutations in genes responsible for maintaining the skin barrier function and regulating the immune system contribute to its development.

This special issue will focus on recent advances in atopic dermatitis research, its pathophysiology, preclinical and clinical studies for drug discovery, including complementary approaches for its treatment. Contributions are welcome from both clinicians and basic researchers involved in all aspects of AD research and healthcare. Biomarker and disease target identification for AD is also solicited for this special issue.

Keywords: Atopic dermatitis, allergy, hypersensitivity, natural products, animal models, mast cells, inflammation