Contents
Special Issue Topic

Drug-induced Liver Injury: From Bench to Clinical Application

Guest Editors

Prof. Jose C Fernandez-Checa E-Mail

Spanish National Research Council at the Institute of Biomedical Research of Barcelona (IIBB-CSIC); Institute of Biomedical Research August Pi i Sunyer (IDIBAPS); CIBEREHD

Research Keywords: Mitochondria, ASH, NASH, liver cancer, cholesterol

Prof. Wen-Xing Ding E-Mail

University of Kansas Medical Center, Kansas City, KS, USA

Research Keywords: Autophagy, mitochondria, alcohol associated liver disease, alcohol-associated pancreatitis, drug-induced liver injury (DILI), lipid metabolism

About the Special lssue

Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and a leading reason for drug withdrawal from the market. Unlike intrinsic DILI, which is predictable, reproducible, and dose-dependent, idiosyncratic DILI is unpredictable, not strictly dose-dependent, and although rare it accounts for 10% to 15% of ALF cases in Western societies. Given the wide use of both prescribed and over the counter drugs, DILI has become a major health issue for which there is a pressing need to find novel and effective therapies. Although significant progress has been made in understanding the molecular mechanisms underlying DILI, our incomplete knowledge of its pathogenesis and inability to predict DILI is largely due to both discordance between human and animal DILI in preclinical drug development and a lack of models that faithfully recapitulate complex pathophysiological features of human DILI. This is exemplified by the hepatotoxicity of acetaminophen (APAP) overdose, a major cause of ALF because of its extensive worldwide use as an analgesic. Despite recent progress with current animal and in vitro models, the mechanisms involved in the hepatotoxicity of APAP are still not fully understood. 

In this Special Issue, we invite experts in the field to cover a wide range of topics of interest in enhancing our current understanding of DILI, from novel technological and in vitro approaches to metabolomics profile and computational modelling as well as clinical implications and registry. Our hope is to collect a state-of-the-art collection of articles that may stimulate mutidisciplinary research in this critical field of basic and clinical liver research.

Keywords: Acetaminophen hepatotoxicity, iPSC, metabolomics, computational modelling, microbiota, idiosyncratic DILI

Published Articles

Open Access Original Article
An analysis on the clinical features and risk factors associated with the prognosis of patients with drug-induced liver injury
Qian Wei ... Jinsheng Guo
Published: June 30, 2023 Explor Dig Dis. 2023;2:100–117
2039 54 1
Open Access Review
Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury
Hanghang Wu ... Francisco Javier Cubero
Published: June 28, 2023 Explor Dig Dis. 2023;2:83–99
4892 74 2
Open Access Review
Liver injury related to Japanese herbal medicines: clinical features and diagnosis
Naoki Mantani
Published: June 27, 2023 Explor Dig Dis. 2023;2:77–82
2102 22 2
Open Access Review
Zebrafish as a model for drug induced liver injury: state of the art and beyond
Gulcin Cakan-Akdogan ... Ozlen Konu
Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
5308 141 3
Open Access Review
Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions
Alejandro Cueto-Sánchez ... Marina Villanueva-Paz
Published: April 26, 2023 Explor Dig Dis. 2023;2:56–76
3060 75 0