Contents
Special Issue Topic

Emerging Nanomedicine Technologies for Enhanced Cancer Theranostics

Submission Deadline: April 30, 2025

Guest Editor

Prof. Xiangyang Shi E-Mail

Professor of Biomedical Engineering, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China

Research Keywords: dendrimers; polymer nanogels; cancer nanomedicine; drug/gene delivery; theranostics

About the Special lssue

Cancer theranostics have been demonstrated as the advanced platforms that can diagnose cancer at early stages and initiate subsequent therapy to impove the survival rate of patients. With the development of nanotechnologies, multifunctional nanoplatforms have shown a good application prospect in enhanced cancer theranostics. Through the ingenious design of nanoplatforms, various imaging and therapeutic agents can be physically loaded or chemically conjugated onto the platforms to optimally exert their functionalities of theranostics. Nanomedicines are contimuously seeking contribution from the therapeutic and diagnostic agents at the nanoscale through creative leveraging of their mechanical, electrical, optical, magnetic, and biological properties. This special issue entitled “Emerging nanomedicine technologies for enhanced cancer theranostics” brings together some of the world's foremost experts to discuss the current key developments in the area of emerging nanomedicine technologies in cancer nanotheranotics, including but not limited to strategic design of nanomedicines to tackcle multi-drug resistance, tumor targeting delivery, modulation of tumor microenvironment, combination therapy, precision imaging, inhibition of cancer metastasis and recurrence, and modulation of immune cells. 

Keywords: drug delivery systems; gene delivery; molecular imaging; cancer theranostics; tumor microenvironment

Published Articles

Open Access Review
Effect of the size of nucleic acid delivery systems on their fate in cancer treatment
Nucleic acid therapeutics are emerging as a promising class of medicines, offering unique therapeutic options for cancer at the gene level. However, the druggability of nucleic acid therapeutics is
Published: February 01, 2024 Explor Drug Sci. 2024;2:38–49
1433 29 3
Open Access Review
Electrospun short fibers: a new platform for cancer nanomedicine applications
With the continuous development of nanomaterials, nanofibers prepared by electrospinning have gradually occupied people’s vision because of their unique advantages, such as crisscross network and
Published: December 27, 2023 Explor Drug Sci. 2023;1:454–467
1866 43 3
Open Access Review
Nano theranostics involved in bladder cancer treatment
Bladder cancer (BC) is a complex disease with multiple clinical manifestations and treatment challenges, and current standard-of-care therapies remain limited and unfavorable. Theranostics, the inte
Published: April 28, 2023 Explor Drug Sci. 2023;1:81–106
2785 57 2
Open Access Original Article
Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA) nanocomposites for killing tumor cells. Methods: MPDA nanoparticles were synthesized and functionalized with camptothecin (CPT) payload and manganese dioxide (MnO2) coating to construct MPDA-CPT-MnO2 nanocomposites. Results: When uptaken by tumor cells, the nanocomposites can degrade to produce O2, release CPT, and generate manganese (Mn2+) under the stimulation of hydrogen peroxide (H2O2) and acid. The released CPT and Mn2+ can act as chemotherapeutic drug and Fenton-like agent, respectively. Abundant reactive oxygen species (ROS) are generated in 4T1 tumor cells through an Mn2+-mediated Fenton-like reaction. After that, the generated Mn4+ can react with glutathione (GSH) through redox reaction to produce Mn2+ and deplete GSH, disrupting the reducing capacity and benefiting the production of ROS in tumor cells. Under laser irradiation, the nanocomposites can generate hyperthermia to promote the production of ROS. Conclusions: The developed MPDA-CPT-MnO2 nanocomposites can kill tumor cells through collaborative chemo/photothermal/chemodynamic therapy (CDT).
Published: February 27, 2023 Explor Drug Sci. 2023;1:18–30
2912 118 0