Exploration of Digestive Diseases

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Open Access Original Article

Fructose induces metabolic reprogramming in liver cancer cells, promoting aggressiveness and chemotherapy resistance

Lisette Chávez-Rodríguez, Alejandro Escobedo-Calvario, Verena Jendrossek, Johann Matschke, Maike Busch, Nicole Dünker, Moisés Vergara-Mendoza, Verónica Souza-Arroyo, Leticia Bucio-Ortiz, Roxana U. Miranda-Labra, Araceli Páez-Arenas, María Concepción Gutié

Published: April 20, 2025 Explor Dig Dis. 2025;4:100572

DOI: https://doi.org/10.37349/edd.2025.100572

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170 14 0

Open Access Perspective

Molecular insights into pancreatic cysts: navigating diagnosis and precision management

Rudy El Asmar, Nazih Bizri, Nikhil Vaishnav Tirukkovalur, Adam Tcharni, Navya Dasyam, Samer AlMasri

Published: April 13, 2025 Explor Dig Dis. 2025;4:100571

DOI: https://doi.org/10.37349/edd.2025.100571

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177 4 0

Open Access Perspective

Debugging surgical guidelines for acute diverticulitis

Valter Nilton Felix

Published: April 11, 2025 Explor Dig Dis. 2025;4:100570

DOI: https://doi.org/10.37349/edd.2025.100570

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110 5 0

Open Access Review

The multiple mechanisms and modes of cell death after acetaminophen overdose

Hartmut Jaeschke, Anup Ramachandran

Published: April 07, 2025 Explor Dig Dis. 2025;4:100569

DOI: https://doi.org/10.37349/edd.2025.100569

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241 9 1

Open Access Original Article

Immune checkpoint inhibitors in patients with advanced gastric cancer: a multi-institutional retrospective real-world study

Anastasia Rays, Мikhail Fedyanin, Dmitriy Popov, Ilya Pokataev, Мarina Lyadova, Lyudmila Zhukova, Daniil Stroyakovskiy, Мikhail Volkonskiy, Natalya Besova, Аlexey Tryakin

Published: March 27, 2025 Explor Dig Dis. 2025;4:100568

DOI: https://doi.org/10.37349/edd.2025.100568

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Open Access Letter to the Editor

Helicobacter pylori infection in the pathophysiology of metabolic dysfunction-associated steatotic liver disease and its complications

Jannis Kountouras, Christos Zavos, Ioannis S. Papanikolaou, Stergios A. Polyzos, Elisabeth Vardaka, Dimitrios Chatzopoulos, Maria Tzitiridou-Chatzopoulou

Published: March 20, 2025 Explor Dig Dis. 2025;4:100567

DOI: https://doi.org/10.37349/edd.2025.100567

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188 5 0

Open Access Review

Drug-induced cholestasis: causative agents and challenges in diagnosis and management

Jose M. Pinazo-Bandera, Juan Pedro Toro-Ortiz, Raúl J. Andrade, Miren García-Cortés

Published: September 18, 2023 Explor Dig Dis. 2023;2:202–222

DOI: https://doi.org/10.37349/edd.2023.00027

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14468 220 3

Open Access Review

Etiopathogenesis and pathophysiology of cholestasis

Maitane Asensio, Sara Ortiz-Rivero, Ana Morente-Carrasco, Jose J. G. Marin

Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117

DOI: https://doi.org/10.37349/edd.2022.00008

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9920 297 2

Open Access Review

Fructose, a trigger of metabolic diseases?—a narrative review

Anja Baumann, Annette Brandt, Ina Bergheim

Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71

DOI: https://doi.org/10.37349/edd.2022.00005

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7409 161 2

Open Access Review

Finn Jung, Victor Sánchez, Annette Brandt, Ina Bergheim

Published: June 30, 2023 Explor Dig Dis. 2023;2:118–132

DOI: https://doi.org/10.37349/edd.2023.00022

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7141 80 3

Open Access Review

Helicobacter pylori and gastric cancer: a critical approach to who really needs eradication

Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki

Published: April 16, 2024 Explor Dig Dis. 2024;3:107–142

DOI: https://doi.org/10.37349/edd.2024.00043

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6003 107 5

Open Access Review

Hepatitis B virus: modes of transmission, immune pathogenesis, and research progress on therapeutic vaccines

Chunzheng Li, Chenyu Wei, Xianguang Yang

Published: October 14, 2024 Explor Dig Dis. 2024;3:443–458

DOI: https://doi.org/10.37349/edd.2024.00060

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5727 104 0

Open Access Review

Etiopathogenesis and pathophysiology of cholestasis

Maitane Asensio, Sara Ortiz-Rivero, Ana Morente-Carrasco, Jose J. G. Marin

Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117

DOI: https://doi.org/10.37349/edd.2022.00008

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9920 297 2

Open Access Review

Drug-induced cholestasis: causative agents and challenges in diagnosis and management

Jose M. Pinazo-Bandera, Juan Pedro Toro-Ortiz, Raúl J. Andrade, Miren García-Cortés

Published: September 18, 2023 Explor Dig Dis. 2023;2:202–222

DOI: https://doi.org/10.37349/edd.2023.00027

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14468 220 3

Open Access Review

Fructose, a trigger of metabolic diseases?—a narrative review

Anja Baumann, Annette Brandt, Ina Bergheim

Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71

DOI: https://doi.org/10.37349/edd.2022.00005

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7409 161 2

Open Access Review

Zebrafish as a model for drug induced liver injury: state of the art and beyond

Gulcin Cakan-Akdogan, Abdul Moiz Aftab, Muazzez Celebi Cinar, Khalid A. Abdelhalim, Ozlen Konu

Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55

DOI: https://doi.org/10.37349/edd.2023.00017

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4650 134 3

Open Access Review

Molecular mechanisms of metabolic disease-associated hepatic inflammation in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

Chunye Zhang, Yuxiang Sui, Shuai Liu, Ming Yang

Published: October 25, 2023 Explor Dig Dis. 2023;2:246–275

DOI: https://doi.org/10.37349/edd.2023.00029

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3728 107 1

Open Access Review

Helicobacter pylori and gastric cancer: a critical approach to who really needs eradication

Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki

Published: April 16, 2024 Explor Dig Dis. 2024;3:107–142

DOI: https://doi.org/10.37349/edd.2024.00043

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6003 107 5

Open Access Editorial

Extra-hepatic cancers in metabolic fatty liver syndromes

Amedeo Lonardo

Published: February 24, 2023 Explor Dig Dis. 2023;2:11–17

DOI: https://doi.org/10.37349/edd.2023.00014

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2143 39 6

Open Access Review

Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications

Zongmei Wu, Mengmeng Xia, Sandra Serna Salas, Maria Camila Trillos-Almanza, Magnolia Martinez Aguilar, Johanna C. Arroyave-Ospina, Junyu Wang, Marco Arrese, Svenja Sydor, Lars P. Bechmann, Frederike GI van Vilsteren, Hans Blokzijl, Han Moshage

Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20

DOI: https://doi.org/10.37349/edd.2022.00002

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Open Access Review

Helicobacter pylori and gastric cancer: a critical approach to who really needs eradication

Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki

Published: April 16, 2024 Explor Dig Dis. 2024;3:107–142

DOI: https://doi.org/10.37349/edd.2024.00043

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6003 107 5

Open Access Review

Principles of risk stratification in nonalcoholic fatty liver disease. A narrative review emphasizing non-invasive strategies

Amedeo Lonardo

Published: August 30, 2023 Explor Dig Dis. 2023;2:188–201

DOI: https://doi.org/10.37349/edd.2023.00026

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2683 54 4

Open Access Review

The central role of mitochondrial metabolism in hepatic steatosis

Sanda Win, Tin Aung Than, Neil Kaplowitz, Nicole Wong, Aliza Arya, Zin Thandar Win, Shwe Hlaing Win, Ei Hnin Phyu, Christina Kuemerle, Jake Suh, Sona Avanesyan, Pujan Prakash Dobaria, Hnin Wai Lwin, Sean Wong, Shannon Kaw, Samuel Wong, Kyaw Khaing Soe, Ga

Published: February 29, 2024 Explor Dig Dis. 2024;3:42–68

DOI: https://doi.org/10.37349/edd.2024.00039

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