Molecular Targets of Diet in Cancer Therapy and Prevention
Sabrina Battista E-Mail
Istituto per l’Endocrinologia e l’Oncologia Sperimentale - CNR
Research Keywords: molecular oncology; transcription factors; stem cells; cancer stem cells; HMGA proteins; adipogenesis; differentiation
In the latest years, diet has been proven to be a precious ally for health and disease prevention. Significantly, it may influence the incidence, growth, and response to therapy of at least some types of cancer. Dietetic regimens and nutrients have been shown to specifically target key molecules, cells (including stem and cancer stem cells), and cellular processes involved in cancer initiation, progression, and drug resistance. The impact of diet on cancer risk and progression has been shown to involve genetics, epigenetics, metabolomics, and individual’s microbiome. However, although nutrition may affect gene expression and cellular response, genetic heterogeneity at the individual and cellular level makes the outcome variable and sometimes unpredictable.
Therefore, a better comprehension of the molecular targets affected by diet can help to design nutritional models more suitable for improving cancer prevention and therapy.
In this special issue, we would like to gather contributions, including original research articles, reviews, commentaries, and hypotheses, which may provide cues into the specific effects of diet on cancer crucial molecules and provide the foundation for future advances.
Keywords: nutrigenomics; targeted diet; nutraceuticals; molecular signature; cancer stem cells; epigenetics; metabolomics; stem cells