Contents
Special Issue Topic

The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease

Guest Editor

Prof. Rafael Franco E-Mail

Professor of Biochemistry and Molecular Biology, Universidad de Barcelona, Barcelona, Spain

Research Keywords: G protein coupled receptors (GPCR); Alzheimer's Disease; Parkinson's disease; neuroprotection; microglia; neurodegeneration

About the Special lssue

The amyloid hypothesis has not led to any effective therapeutic intervention for the management of Alzheimer's disease (AD). The controversy over whether protein aggregation is the cause or consequence of AD is no longer relevant. The urgent thing is to formulate hypotheses that can explain why neurons begin to suffer and finally die and cause the disease. This special issue seeks strong hypotheses as well as novel contributions focused primarily on the patient and taking data from patients, ranging from the type of profession to the events, emotional or clinical, surrounding the date of onset. Also welcome are ideas on novel public health studies to correlate lifestyle, neurological and non-neurological diseases, medication, etc., with the onset and progression rate of the disease. The special issue is open both to novel hypotheses, based on scientific criteria, and to studies in patients and controls, regardless of whether they are carried out in a small number of individuals.

Keywords: Alzheimer’s disease; neuroprotection; public health; epidemiological studies; neuronal death; neuronal survival; synaptic plasticity

Published Articles

Open Access Mini Review
Impaired glymphatic clearance is an important cause of Alzheimer’s disease
Iyawnna Hazzard ... Forshing Lui
Published: October 24, 2024 Explor Neuroprot Ther. 2024;4:401–410
3267 48 0
Open Access Perspective
“Vitaction” deficiency: a possible root cause for multiple lifestyle disorders including Alzheimer’s disease
Milind Watve, Ashwini Keskar Sardeshmukh
Published: April 07, 2024 Explor Neuroprot Ther. 2024;4:108–118
2048 34 2
Open Access Original Article
Cannabinoid CB2 receptor ligands disrupt the sequential regulation of p-MEK1/2 to p-ERK1/2 in mouse brain cortex
Glòria Salort ... Jesús A. García-Sevilla
Published: October 24, 2023 Explor Neuroprot Ther. 2023;3:258–267
1565 35 1
Open Access Original Article
Alzheimer’s disease detection from magnetic resonance imaging: a deep learning perspective
Karolina Armonaite ... Luigi Laura
Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:139–150
2854 71 2
Open Access Review
Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy
Jesús Avila ... Félix Hernández
Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:151–163
2325 59 1
Open Access Review
Can chronic therapeutic drug use by the elderly affect Alzheimer’s disease risk and rate of progression?
Rafael Franco, Joan Serrano-Marín
Published: February 27, 2023 Explor Neuroprot Ther 2023;3:8–23
2235 40 5