This special issue aims to explore various strategies and interventions that promote neuroprotection in the context of mental illnesses. With the growing recognition of the role of neuroplasticity and neurodegeneration in the pathophysiology of mental disorders, there is a need to identify and evaluate novel therapeutic approaches that can enhance the resilience of the nervous system and improve mental health outcomes. The scope of this special issue includes the development and evaluation of new therapies, as well as investigations of existing therapies and their mechanisms of action to feature original research articles, reviews, and commentaries that address the following topics (but not limited to):

• Pharmacological interventions that target neuroprotective pathways in mental illnesses

• Nutritional and lifestyle interventions that support brain health and resilience

• Psychosocial interventions that enhance neural plasticity and cognitive function

• Neuroimaging and biomarker studies that assess the effectiveness of neuroprotective therapies

• Policy and practice implications of neuroprotective approaches in mental health care

We welcome multidisciplinary research using innovative methods such as neuroimaging, genetics, and pharmacology. Join us in advancing our understanding and treatment of mental illnesses through cutting-edge research!

Keywords: mental health disorders; neuroprotective agents; nootropic agents; antidepressive agents; mood disorders; cognitive dysfunction; psychopharmacology; psychoneuroimmunology