Contents
Special Issue Topic

Cholesterol Dyshomeostasis in Neurological Diseases

Guest Editors

Dr. Ta-Yuan Chang E-Mail

Professor, Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

Research Keywords: cholesterol metabolism; membrane proteins; Alzheimer's disease; NPC disease; Vascular dementia

Dr. Catherine Chang E-Mail

Principal Research Scientist, Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA

Research Keywords: cholesterol metabolism; structure and function analysis of ACAT/SOAT; membrane proteins; Alzheimer's disease; NPC disease

About the Special lssue

Cholesterol is a lipid molecule that is essential to the structure and function of biological membranes, as well as the growth and maintenance of all mammalian cells. The metabolites of cholesterol, including oxysterols, neurosteroids, and bile acids, play important regulatory roles in mammalian physiology. Increasing evidence implicates the involvement of cholesterol dyshomeostasis in diverse neurological diseases, including Alzheimer's disease, autism, Huntington disease, multiple sclerosis, Niemann-Pick type C disease, Smith-Lemli-Opitz syndrome, and vascular dementia. The mechanistic connections between cholesterol and the pathophysiology of these diseases are as yet inadequately understood.

To stimulate research in this burgeoning area, we are organizing a special issue of the Journal, entitled “Cholesterol Dyshomeostasis in Neurological Diseases,” that will contain several invited reviews written by leading scientists in the relevant research fields. We are also soliciting additional relevant manuscripts that describe original research, meta-analysis, commentary, or editorial. Manuscripts that address the following areas will be particularly welcome: roles of cholesterol or its metabolites in the brain; brain-penetrating agents to facilitate CNS cholesterol homeostasis; and neurological alterations caused by cholesterol imbalance in the CNS or by hypercholesterolemia and atherosclerosis.

Each qualified manuscript will undergo prompt and thorough peer-review. The published issue will receive wide promotion by the Journal to the international scientific community. The goal of this special issue is ultimately to stimulate the discovery and development of novel, cholesterol-related neuroprotective therapies by scientists working in the basic, translational, and clinical neuroscience arenas. This issue can also be used as a timely resource for graduate students and postdoctoral fellows entering the field of neurodegeneration research.

Keywords: cholesterol; membranes; neuroscience; neuroprotective therapies; neurological disease

Published Articles

Open Access Review
Balancing cholesterol in the brain: from synthesis to disposal
Lydia Qian ... Andrew J. Brown
Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
12816 446 12
Open Access Review
Blocking cholesterol storage to treat Alzheimer’s disease
Ta Yuan Chang ... James G. Gow
Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:173–184
4618 109 18
Open Access Review
Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases
Irina A. Pikuleva
Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:159–172
3539 99 4
Open Access Review
Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
Xuntian Jiang, Daniel S. Ory
Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:146–158
3809 98 17
Open Access Review
Peroxisomes in intracellular cholesterol transport: from basic physiology to brain pathology
Jian Xiao ... Jie Luo
Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:127–145
5367 154 3
Open Access Review
Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
Kamran Tariq, Bryan W. Luikart
Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
10266 329 32
Open Access Review
Cholesterol in autism spectrum disorders
Rafael Franco ... Irene Reyes-Resina
Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:10–18
5671 117 0