Contents
Special Issue Topic

Lung Fibrosis—Models and Mechanisms

Submission Deadline: June 30, 2025

Guest Editor

Prof. Bernhard Ryffel E-Mail

Professor, INEM, UMR7355, CNRS, University of Orleans, Orleans, France

Research Keywords: Mechanisms of inflammation, innate immune danger sensing, inflammasome activation, IL-33 and Th17/Th22 differentiation

About the Special lssue

The lung is a critical organ for gas exchange and overall health. Chronic environmental exposures may cause injury to the respiratory barrier, leading to inflammation, emphysema, and progressive interstitial fibrosis, ultimately resulting in respiratory failure. This special issue will begin with an overview of human fibrotic diseases and then address the following key topics:

  • Aerosol and systemic exposure to particles, smoke, allergens, chemicals, ozone, radiation, as well as viral, bacterial, parasitic, and helminth infections.

  • Clinical perspectives on COPD, including rodent and in vitro models, and their predictive value for COPD.

  • Idiopathic pulmonary fibrosis (IPF) and preclinical models.

  • Molecular mechanisms of fibrosis progression and cell death pathways.

  • The role of TLR, inflammasomes, DNA sensing, and cross-talk between pathways.

  • Inflammaging, senescence, and autophagy.

  • Inflammatory cytokines such as TNF and IL-1 family members, and growth factors.

  • The contribution of intestinal microbiota and metabolism, including SCFA, tryptophan, and serotonin.

  • Prevention and therapy: new therapeutic targets and drug candidates.

Keywords: TNF, IL-1, growth factors, NLRP, TLR, autophagy, senescence, pollution, microbiome, metabolites, disease models

Published Articles

Open Access Review
Mechanism of lungs fibrosis in mycobacterial infection
Lena B. Kim, Anna N. Putyatina
Published: December 12, 2023 Explor Med. 2023;4:956–976
4531 67 0
Open Access Original Article
Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D
Mauro G. Silva ... Walter Manucha
Published: April 26, 2023 Explor Med. 2023;4:246–253
1603 30 1