Contents
Special Issue Topic

Exploring NAFLD/NASH

Guest Editors

Dr. Amedeo Lonardo E-Mail

Director of Simple Operating Unit, Ospedale Civile di Baggiovara, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy

Research Keywords: NAFLD, NASH, cirrhosis, HCC

Dr. Giovanni Targher E-Mail

Section of Endocrinology and Metabolism, Department of Medicine, University of Verona, Verona, Italy

Research Keywords: Role of NAFLD in cardiovascular morbidity/mortality, role of NAFLD in microvascular complications of diabetes

About the Special lssue

Exploration of Medicine (EM) is a novel peer-reviewed, open access, online journal. It publishes articles that provide substantial and novel insights into medicine spanning molecular and cell biology through research of all human diseases. The journal adopts a single-blind peer review. Those authors who publish for EM hold the copyright of their works, make their original works completely available and free to use as long as the authors and the original source are properly cited.

EM has charged two Associate Editors, Dr. Lonardo (Gastroenterology & Hepatology) and Professor Targher (Endocrinology & Metabolism) to edit a special issue dedicated to nonalcoholic fatty liver disease (NAFLD). Why has this topic been chosen? NAFLD defines a spectrum of hepatic (steatosis, nonalcoholic steatohepatitis [NASH], cirrhosis and hepatocellular carcinoma) and extra-hepatic manifestations (nephro-cardio-metabolic diseases and extra-hepatic cancers) that occur in individuals free of any competing causes of hepatic steatosis (e.g., alcohol, virus, drugs and others) but who often have concurrent dysmetabolic features. NAFLD is the most common chronic liver disease worldwide, causes considerable health care expenses, requests a heavy toll in terms of morbidity and premature mortality and has, therefore, gained considerable scientific interest. Areas of ongoing research include epidemiological features and risk factors, (molecular) pathogenesis, (non-invasive) diagnosis, government of the patients fluxes from primary to specialist care as well as management of this burdensome liver disease with lifestyle modifications and innovative drugs that are being evaluated.

In order to provide a virtual forum for exchange of ideas and data in Academic as well as in Translational and Clinical research, Dr. Lindsay Farrer, the Editor-in-Chief of EM, has invited Doctors Lonardo and Targher to edit this single-topic issue.

Keywords: NAFLD, NASH, HCC, cirrhosis

Published Articles

Open Access Review
Pediatric vs. adult NAFLD to MAFLD transition: a welcome but tangled path
Angelo Colucci ... Claudia Mandato
Published: August 31, 2021 Explor Med. 2021;2:333–342
3345 95 3
Open Access Review
Sex hormones abnormalities in non-alcoholic fatty liver disease: pathophysiological and clinical implications
Angelo Di Vincenzo ... Marco Rossato
Published: August 31, 2021 Explor Med. 2021;2:311–323
5609 86 0
Open Access Review
Cardiovascular involvement after liver transplantation: role of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
Rosa Lombardi ... Anna Ludovica Fracanzani
Published: February 28, 2021 Explor Med 2021;2:20–38
3293 41 0
Open Access Review
The diagnostic conundrum in non-alcoholic fatty liver disease
Valerio Rosato ... Marcello Persico
Published: October 30, 2020 Explor Med. 2020;1:259–286
7844 188 6
Open Access Review
Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
Carlo Acierno ... Ferdinando Carlo Sasso
Published: October 30, 2020 Explor Med. 2020;1:287–306
9614 341 54
Open Access Review
Non-alcoholic fatty liver disease and transient elastography
Ivana Mikolasevic ... Sandra Milic
Published: August 31, 2020 Explor Med. 2020;1:205–217
6261 81 4
Open Access Review
Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
Fatiha Nassir
Published: August 31, 2020 Explor Med. 2020;1:248–258
5905 113 9
Open Access Review
Genetic and metabolic factors: the perfect combination to treat metabolic associated fatty liver disease
Marica Meroni ... Paola Dongiovanni
Published: August 31, 2020 Explor Med. 2020;1:218–243
5832 111 4
Open Access Review
The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis
Michael Doulberis ... Stergios A. Polyzos
Published: August 31, 2020 Explor Med. 2020;1:170–183
5295 72 5
Open Access Review
Perspectives of nonalcoholic fatty liver disease research: a personal point of view
Amedeo Lonardo, Stefano Ballestri
Published: June 29, 2020 Explor Med. 2020;1:85–107
8771 130 25
Open Access Review
Nonalcoholic fatty liver disease and portal hypertension
Marvin Ryou ... Gyorgy Baffy
Published: June 29, 2020 Explor Med. 2020;1:149–169
9368 139 29
Open Access Review
Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
Noel C. Salvoza ... Natalia Rosso
Published: April 30, 2020 Explor Med. 2020;1:51–74
12443 252 20