Contents
Special Issue Topic

Gut Microbiota Derived Metabolites and Chronic Inflammatory Diseases

Submission Deadline: May 30, 2025

Guest Editor

Dr. Zeneng Wang E-Mail

Staff Scientist, Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, USA

Research Keywords: Gut microbiome, cardiovascular disease, atherosclerosis, metabolomics, mass spectrometry

About the Special lssue

Microbes inhabit human gut with a number reaching trillions, higher than the cell number composing human body and total genome size 150 times as long as human genome. Gut microbiota plays important roles in human health, which include maintaining gut barrier, helping digesting food, producing vitamins, preventing pathogen overgrowth and modulating human immunity as well. Gut microbiota is involved in synthesis of some bioactive metabolites, which circulate in human blood and are delivered to different target tissues, mediating the effects of gut microbiota. So gut microbiota is regarded as the largest endocrine organ. There are hundreds of gut microbiota derived metabolites reported. Some of them, such as short chain fatty acids, which are the fermented metabolites of dietary fiber, can maintain gut barrier, induce release of gut hormones, peptide YY (PYY) and glucagon like peptide 1 (GLP-1), to modulate satiety, energy harvest and fat storage and inhibit inflammation. Some of them, such as trimethylamine N-oxide, p-cresyl sulfate and indoxyl sulfate, show pro-inflammatory effects, leading to enhanced chronic inflammatory diseases. Recently gut microbiota metabolites of tryptophan, indole acetic acid and indole-3-propionic acid, have been reported to enhance sensitivity of chemotherapy against cancer. Targeting gut microbiota derived metabolites will become a strategy to treat chronic diseases. In this special issue, we will discuss the roles of gut microbiota derived metabolites in inflammatory chronic diseases, which will provide important clues to prevent and treat the diseases.

Published Articles

Open Access Review
The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD)
Shin Takasawa ... Maiko Takeda
Published: February 05, 2025 Explor Med. 2025;6:1001278
412 14 0
Open Access Review
Gut microbiota-derived metabolites and chronic inflammatory diseases
Alejandra Vargas ... David A. Johnson
Published: January 19, 2025 Explor Med. 2025;6:1001275
990 22 0
Open Access Review
Natural polysaccharides-based postbiotics and their potential applications
Weinan Du ... Juxiu Li
Published: June 28, 2024 Explor Med. 2024;5:444–458
1908 42 0
Open Access Original Article
Analysis of microbiocenosis of a gingival sulcus and periodontal pockets of patients with periodontal diseases associated with systemic pathology
Olha Denefil ... Khrystyna Loza
Published: December 11, 2023 Explor Med. 2023;4:942–955
2121 38 3