Contents
Special Issue Topic

Breast Cancer: Basic and Clinical Advances

Guest Editor

Dr. Andrea Nicolini E-Mail

Department of Oncology, Transplantations and New Technologies in Medicine, University of Pisa, Pisa, Italy

About the Special lssue

Breast cancer is the most common malignancy worldwide and in females, with a social impact that underlines the relevance of any advances in basic and clinical research. In the last decades, much progress has been made in the comprehension of the molecular mechanisms sustaining tumor growth and diffusion, and certainly a large part of this research has been devoted to breast cancer. As a result of such intense investigation, many mechanisms have been elucidated, and a few targeted therapies through translational research have been introduced into current clinical practice. This is also named as "personalized" or "precision" medicine. This special issue aims to collect any useful scientific contributions in the breast cancer research field , either research or review articles that provide readers with information easy to catch and at the same time in line with the currently evolving studies.

Keywords: Breast cancer, basic research, clinical research, molecular mechanisms, chemotherapy, immunotherapy

Published Articles

Open Access Original Article
Prevalence of HPV, EBV, MMTV and SV40 co-infection in women with invasive breast cancer: as a potential new viral etiology
Aim: Breast cancer (BC) is the leading cause of female cancer-related death worldwide. The high incidence of BC has sparked interest in the viral agents role in its development. Identifying co-in
Published: April 16, 2025 Explor Med. 2025;6:1001304
137 4 0
Open Access Case Report
Pembrolizumab associated hypereosinophilia in locally advanced triple-negative breast cancer
The advent of immunotherapy has revolutionized the therapeutic landscape of breast cancer. The immune checkpoint inhibitor drug, pembrolizumab, a monoclonal antibody targeting programmed cell death
Published: March 13, 2025 Explor Med. 2025;6:1001294
371 10 0
Open Access Original Article
Association between GPX4 and HMGCR gene expression and cell proliferation in atypical hyperplasia of the breast
Aim: Using a dataset available from the NCBI Gene Expression Omnibus Repository, this in silico study investigated the differential expression of GPX4, the gene coding for the detoxifying enzyme
Published: December 15, 2024 Explor Med. 2024;5:950–959
721 26 0
Open Access Review
Role of transcription factors in metastasis of breast cancer
Metastasis causes a majority of deaths in breast cancer patients. Metastasis is the spread of cancer to distant sites in the body away from the primary tumor, creating secondary tumors, or metastase
Published: December 09, 2024 Explor Med. 2024;5:936–949
969 34 0
Open Access Mini Review
Navigating breast health: a comprehensive approach to atypical ductal hyperplasia of the breast management and surveillance
Atypical ductal hyperplasia (ADH) is a benign lesion of the breast that is associated with an increased risk of invasive breast cancer. This review explores the pathophysiology, risk factors for pro
Published: February 07, 2024 Explor Med. 2024;5:59–64
3390 46 0
Open Access Original Article
Cholesterol de novo biosynthesis: a promising target to overcome the resistance to aromatase inhibitors in postmenopausal patients with estrogen receptor-positive breast cancer
Aim: Cholesterol is an essential component of cell membranes and serves as a precursor for several bioactive molecules, including steroid hormones and isoprenoids. Generally supplied by the blood
Published: December 29, 2023 Explor Med. 2023;4:1079–1093
2286 26 1
Open Access Review
The differential effect of the immune system in breast cancer
Cancer cure with immunotherapy is an innovative step towards cancer treatment with better survivability, but it is mostly dependent on the response of the patient’s immune system to the immunother
Published: December 29, 2023 Explor Med. 2023;4:1094–1108
3615 62 2
Open Access Original Article
Impact of the type of breast cancer on the biodiversity of the vaginal Candida represented by estrogen receptor and its levels
Aim: Estrogen has an important role in the colonization of Candida through the presence of estrogen receptors (ERs). These ERs are usually used to categorize breast cancer into two types, positiv
Published: December 06, 2023 Explor Med. 2023;4:878–885
2915 24 0