Integrated Approaches for Non-Small-Cell Lung Cancer
Guest Editors
Dr. Alessandro Morabito E-Mail
Director of Thoracic Medical Oncology, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy
Research Keywords: Lung cancer; target based agents; angiogenesis inhibitors; immunotherapy; clinical trials
Dr. Edoardo Mercadante E-Mail
Director of Thoracic Surgery Unit, National Cancer Institute IRCCS ”Pascale Foundation”, Naples, Italy
About the Special lssue
The treatment landscape of patients with non-small-cell lung cancer (NSCLC) has dramatically changed in recent years, thanks to the improvement in the knowledge of the biology of NSCLC, the discovery of targetable oncogenic drivers, the positive results obtained with immunotherapy in different settings (advanced, locally advanced, adjuvant, neoadjuvant) and the optimal integration of surgery, radiotherapy and systemic treatments. Furthermore, thanks to the advent of technology, surgical minimally invasive treatments (Robotic and Thoracoscopic) are always less traumatic, thus, increasing the number of surgical candidates, even in fragile and with co-morbidities patients.
For NSCLC patients with early and locally advanced disease a through therapeutic revolution is currently ongoing and a multidisciplinary approach is mandatory. This Special Issue will highlight the current state of treatment of early and locally advanced NSCLC patients, focusing on the approved indications of surgery, radiotherapy and systemic treatments, including chemotherapy, immunotherapy and targeted based agents. Moreover, the strategies to improve the results obtained to date and the challenge to face resistance disease will be discussed. Finally, the role of liquid biopsy in this setting and its potential implementation will be evaluated.
The possible topics could be (but not limited to) :
The role of radioterapy in early stage NSCLC
Advancement in radiotherapy for locally advanced NSCLC
New surgical approaches for early stage NSCLC
Role of surgery for locally advanced NSCLC
Immunotherapy for locally advanced NSCLC
Target based agents for oncogene addicted locally advanced NSCLC
The role of liquid biopsy in early stage NSCLC
Advancement in the treatment of locally advanced NSCLC
Minimally invasive surgery and its efficacy on lymphadenectomy
Activity of a Lung Cancer MDT: benefits and barriers
Keywords: Early stage NSCLC; locally advanced NSCLC; thoracic radiotherapy; thoracic surgery; adjuvant treatment; liquid biopsy; immunotherapy
Published Articles
