Contents
Special Issue Topic

Calcium Signaling Apparatus in Cancers

Guest Editor

Dr. Zui Pan E-Mail

College of Nursing and Health Innovation, The University of Texas at Arlington, TX, USA

Research Keywords: Esophageal cancer; calcium signaling; store-operated calcium entry; live cell imaging; chemotherapy

About the Special lssue

Dysregulated intracellular Ca2+ signaling is associated with the development of malignant phenotypes. Cancer cells remodel their Ca2+ signaling apparatus to enhance proliferation, to increase cell motility and invasion, to resist apoptosis, to escape from immune-attack, or to have neovascularization. There has been an increasing awareness that tumorigenic pathways are associated with altered expression or abnormal activation of Ca2+ channels, transporters or Ca2+-pumps. Targeting the altered Ca2+ signaling apparatus to develop new anti-cancer drugs is emerging, yet many challenges remains. Intracellular Ca2+ homeostasis plays important role in normal physiology and cell functions; thus, it is important to identify the cancer specific properties of the Ca2+ apparatus. Different cancers or different stages during tumor development may present distinct different alteration in Ca2+ signaling apparatus. More specific, more potent and less off-target compounds targeting Ca2+ channels/transporters/pumps are urgently needed.
This special issue will highlight the current state of diverse molecular mechanisms of intracellular Ca2+ involved in cell proliferation, apoptosis, migration, invasion, or angiogenesis in different cancers. It will also discuss developing effective novel cancer treatment targeting Ca2+ channels, transporters or Ca2+-pumps.

Keywords: Calcium channels; cell proliferation; apoptosis; migration; metastasis; transcription factors; chemotherapy

Published Articles

Open Access Review
Roles of calcium signaling in cancer metastasis to bone
Tianying Xie ... Jianru Xiao
Published: August 31, 2022 Explor Target Antitumor Ther. 2022;3:445–462
3327 64 10
Open Access Review
Targeting the two-pore channel 2 in cancer progression and metastasis
Kathryn A. Skelding ... Lisa F. Lincz
Published: February 28, 2022 Explor Target Antitumor Ther. 2022;3:62–89
3958 71 10
Open Access Original Article
Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma
Alana L. Cutliffe ... John J. Mackrill
Published: December 31, 2021 Explor Target Antitumor Ther. 2021;2:543–575
3523 59 2
Open Access Review
A novel strategy for treating cancer: understanding the role of Ca2+ signaling from nociceptive TRP channels in regulating cancer progression
Wen-Li Hsu ... Etsuro Ito
Published: October 31, 2021 Explor Target Antitumor Ther. 2021;2:401–415
3588 72 1
Open Access Review
Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets
Chaochu Cui ... Xianwei Wang
Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:266–291
4836 135 1
Open Access Review
Overview of Ca2+ signaling in lung cancer progression and metastatic lung cancer with bone metastasis
Manh Tien Tran
Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:249–265
3623 54 3
Open Access Original Article
Understanding doxorubicin associated calcium remodeling during triple-negative breast cancer treatment: an in silico study
Garhima Arora ... Samrat Chatterjee
Published: April 30, 2021 Explor Target Antitumor Ther. 2021;2:208–226
4047 123 0