Contents
Special Issue Topic

Predictive and Prognostic Biomarkers in Cancer: Towards the Precision Medicine Era

Submission Deadline: February 28, 2025

Guest Editors

Prof. Luca Falzone E-Mail

Department of Biomedical and Biotechnological Sciences, University of Catania, Italy

Research Keywords: Molecular oncology, epigenetics, biomarker discovery, liquid biopsy

Dr. Antonio Rizzo E-Mail

Division of Pathology, Humanitas Istituto Clinico Catanese, Catania, Italy

Research Keywords: Breast cancer, pathology, immunohistochemistry, molecular pathology

Dr. Stefano Marletta E-Mail

Division of Pathology, Humanitas Istituto Clinico Catanese, Catania, Italy; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Italy

Research Keywords: Digital pathology, cancer immunity, immunopathology, immunohistochemistry

Dr. Graziana Spoto E-Mail

Division of Pathology, Humanitas Istituto Clinico Catanese, Catania, Italy

Research Keywords: Oncogenetics, hereditary tumors, molecular biology, molecular diagnostics, predictive biomarkers

About the Special lssue

In recent years, cancer research has experienced significant advancements in understanding the molecular mechanisms associated with the development and progression of tumors. These advancements have highlighted the importance of predictive and prognostic biomarkers in guiding therapeutic decisions and improving clinical outcomes. Predictive biomarkers are crucial for identifying patients likely to respond to specific treatments, while prognostic biomarkers provide information on disease progression regardless of the therapy received.

This special issue is dedicated to the exploration and characterization of predictive and prognostic biomarkers in the context of cancer diagnosis and management, aiming to promote the era of precision medicine. We invite contributions covering a wide range of topics, including but not limited to the discovery of new biomarkers through already acknowledged and novel advanced technologies, such as immunohistochemistry and next-generation sequencing; the clinical application and meaning of existing biomarkers; technological advancements in biomarker discovery and analysis; case studies on the successful implementation of precision medicine in oncology. Studies exploring the integration of omics data, bioinformatics, and artificial intelligence for identifying and validating biomarkers will be particularly appreciated. Additionally, we welcome research examining the role of epigenetic biomarkers, tissue markers (i.e. immunohistochemistry, in situ hybridization techniques), liquid biopsies, and circulating tumor cells in early diagnosis, prognosis, and drug resistance.

This special issue aims to bring together researchers, clinicians, and translational scientists to discuss the latest discoveries and future directions in predictive and prognostic biomarker research. Our goal is to foster interdisciplinary collaborations and accelerate the implementation of precision medicine strategies in cancer treatment.

Keywords: Predictive biomarkers, prognostic biomarkers, precision medicine, cancer genomics, molecular oncology, next-generation sequencing, bioinformatics, multi-omics, liquid biopsy

Published Articles

Open Access Original Article
Mutational landscape of epidermoid carcinoma of the penis in a Brazilian cohort
Renato Mendes Rossi De Lucca ... Rodolfo Borges dos Reis
Published: June 06, 2025 Explor Target Antitumor Ther. 2025;6:1002323
411 10 0
Open Access Review
Exploring recent advances in signaling pathways and hallmarks of uveal melanoma: a comprehensive review
Majid Banimohammad ... Hamidreza Pazoki-Toroudi
Published: April 02, 2025 Explor Target Antitumor Ther. 2025;6:1002306
1417 30 1
Open Access Editorial
Predictive and prognostic biomarkers in cancer: towards the precision medicine era
Stefano Marletta ... Luca Falzone
Published: November 20, 2024 Explor Target Antitumor Ther. 2024;5:1321–1325
1626 33 4