Contents
Special Issue Topic

The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor

Guest Editors

Dr. Erika Martinelli E-Mail

Associate Professor in Medical Oncology, Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy

Research Keywords: colorectal cancer; translational research; resistance to targeted therapies; gastrointestinal cancer

Dr. Giulia Martini E-Mail

University of Campania “Luigi Vanvitelli”, Naples, Italy

About the Special lssue

This special issue is dedicated to the implementation of liquid biopsy in clinical practice for different solid tumors. Nowadays, tissue genotyping represents a major challenge in oncology due the limit to not completely catch the complex molecular pattern of heterogeneous tumors and the invasiveness and costs of techniques that often limit a fully understanding of cancer landscape along the course of tumor disease. Liquid biopsy analysis has the potential to overcome tumor-biopsy limitations allowing to a longitudinal, comprehensive, and non-invasive monitoring of disease. Remarkably, circulating tumor DNA analysis has the potential to guide treatment decision, monitor response and early catch treatment resistance. Moreover, liquid biopsy analysis has been recently used for the detection of minimal residual disease (MRD), which reflects the presence of tumor cells left after surgery or local treatment or disseminated from the primary tumor in patients with no sign of clinical or radiological progression. 

The aim of this special issue is to collect original translational research data on the discovery of new blood-based cancer biomarkers and updated reviews of the literature to highlight recent discoveries in the field of precision medicine.

Keywords: Precision medicine; liquid biopsy; circulating tumor DNA; biomarker; treatment resistance

Published Articles

Open Access Review
Clinical relevance of circulating tumor DNA in ovarian cancer: current issues and future opportunities
Elena Trevisi ... Ilaria Colombo
Published: June 19, 2024 Explor Target Antitumor Ther. 2024;5:627–640
1993 36 1
Open Access Original Article
Chemotherapy related changes in cfDNA levels in squamous non-small cell lung cancer: correlation with symptom scores and radiological responses
Nithiyanandan Ravi ... Navneet Singh
Published: May 28, 2024 Explor Target Antitumor Ther. 2024;5:508–521
1102 16 0
Open Access Original Article
Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers
Lisa T. Huber ... Cornelia Brunner
Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:422–446
2103 29 6
Open Access Review
Diagnostic value of liquid biopsy in the era of precision medicine: 10 years of clinical evidence in cancer
Vincenza Caputo ... Stefania Napolitano
Published: February 28, 2023 Explor Target Antitumor Ther 2023;4:102–138
5165 124 38
Open Access Review
Clinical utility of liquid biopsy-based companion diagnostics in the non-small-cell lung cancer treatment
Yoshiharu Sato
Published: October 31, 2022 Explor Target Antitumor Ther. 2022;3:630–642
2827 32 13
Open Access Review
Clinical applications of liquid biopsy in HPV-negative and HPV-positive head and neck squamous cell carcinoma: advances and challenges
Mariana Chantre-Justino ... Lucas Delmonico
Published: August 31, 2022 Explor Target Antitumor Ther. 2022;3:533–552
3089 70 4
Open Access Review
Liquid biopsy in biliary tract cancer from blood and bile samples: current knowledge and future perspectives
Gianluca Arrichiello ... Emilio Francesco Giunta
Published: June 22, 2022 Explor Target Antitumor Ther. 2022;3:362–374
2672 54 9