Contents
Special Issue Topic

Targeting Transcription Factors for Cancer Therapy

Guest Editor

Dr. Gautam Sethi E-Mail

Associate Professor, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Research Keywords: signal transduction; apoptosis; transcription factors; metastasis; mouse models of cancer

About the Special lssue

Transcription factors play an important role in regulating gene expression by binding to specific DNA sequences. However, once deregulated several transcription factors can mediate ontogenesis and mediate tumor initiation, promotion and progression. They can regulate a number of genes involved in abnormal proliferation, survival, angiogenesis, and metastasis of tumor cells. A number of pharmacological strategies have been employed to target the aberrant activation of transcription factors to control tumorigenesis. These include approaches to affect their expression, by mitigating protein/protein interactions, and by preventing their DNA binding at specific DNA-interacting sites. This special issue will highlight these strategies and the potential utility of these transcription factors as “druggable targets”.

Keywords: transcription factors; cancer; gene expression; apoptosis; small molecules

Published Articles

Open Access Review
Emerging role of pioneer transcription factors in targeted ERα positive breast cancer
Honey Pavithran, Ranjith Kumavath
Published: February 28, 2021 Explor Target Antitumor Ther. 2021;2:26–35
3897 65 1
Open Access Review
An overview of the potential anticancer properties of cardamonin
Shanaya Ramchandani ... Manoj Garg
Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:413–426
5605 68 8
Open Access Review
Targeting transcription factors in cancer drug discovery
Partha Mitra
Published: December 28, 2020 Explor Target Antitumor Ther. 2020;1:401–412
6103 230 4
Open Access Review
Potential of guggulsterone, a farnesoid X receptor antagonist, in the prevention and treatment of cancer
Sosmitha Girisa ... Ajaikumar B. Kunnumakkara
Published: October 30, 2020 Explor Target Antitumor Ther. 2020;1:313–342
5428 75 17
Open Access Review
Possible applications of salvianolic acid B against different cancers
Iram Shahzadi ... Reza Mohammadinejad
Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:218–238
4263 40 9
Open Access Review
A brief overview of antitumoral actions of bruceine D
Zi Wayne Sin ... Manoj Garg
Published: August 31, 2020 Explor Target Antitumor Ther. 2020;1:200–217
4468 67 9
Open Access Review
An overview of the anti-cancer actions of Tanshinones, derived from Salvia miltiorrhiza (Danshen)
Irum Naz ... Kwang Seok Ahn
Published: June 29, 2020 Explor Target Antitumor Ther. 2020;1:153–170
6596 104 16