Contents
Special Issue Topic

​Liquid Biopsy: Has Already Changed the Clinical Decision-Making in Solid Tumors Treatment?​​

Submission Deadline: June 30, 2025

Guest Editor

Dr. Giulia Martini E-Mail

University of Campania “Luigi Vanvitelli”, Naples, Italy

Research Keywords: Colorectal cancer, translational research, resistance to targeted therapies, gastrointestinal cancer

About the Special lssue

This special issue is dedicated to the incorporation of liquid biopsy in clinical decision making for solid tumors. Liquid biopsy is a non-invasive tool that could overcome tissue genotyping limits, providing a more complete molecular profiling that could catch the complex molecular pattern of heterogeneous tumors along the course of tumor disease. Remarkably, the role of circulating tumor DNA analysis has been well established in metastatic setting, in which could potentially guide treatment decision, monitor response and early catch treatment resistance. Moreover, very interesting data come from the use of ctDNA in the early stage of tumors, for the early detection and the detection of minimal residual disease (MRD), which reflects the presence of tumor cells left after surgery or local treatment or disseminated from the primary tumor in patients with no sign of clinical or radiological progression.

The aim of this special issue is to collect original translational research data and updated reviews on the use of liquid biopsy in oncology, to provide optimal patient selection for chemotherapy, targeted agents and immunotherapy and explore the role of ctDNA as a potential prognostic and predictive biomarker in oncologic diseases.

Keywords: Precision medicine, liquid biopsy, circulating tumor DNA, biomarker, treatment resistance, minimal residual disease

Published Articles

Open Access Review
Biliary tract cancers: advances in diagnostic and management
James Gutmans, Hiba Mechahougui
Published: June 23, 2025 Explor Target Antitumor Ther. 2025;6:1002328
152 10 0
Open Access Review
Circulating tumor cells: overcoming challenges of detecting a needle in a haystack
Zhuldyz Myrkhiyeva ... Aliya Bekmurzayeva
Published: May 29, 2025 Explor Target Antitumor Ther. 2025;6:1002321
603 18 0
Open Access Commentary
The role of circulating tumor DNA (ctDNA) in urothelial cancers
Jeanny B. Aragon-Ching
Published: May 19, 2025 Explor Target Antitumor Ther. 2025;6:1002317
448 19 0