Over the past few decades, research in this field has uncovered a profound understanding of how these transcripts contribute to cancer initiation, progression, and therapeutic responses. While the spotlight of cancer research has so far been on protein-coding genes, the discovery of the vast landscape of ncRNAs is revolutionizing our comprehension of the molecular mechanisms underlying cancer.

Non-coding RNAs, once considered transcriptional noise, have emerged as critical regulators of gene expression and cellular processes. From microRNAs (miRNAs) to long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), these molecules exert multifaceted effects on tumor biology by modulating pathways involved in proliferation, apoptosis, invasion, and metastasis. Furthermore, ncRNAs exhibit remarkable tissue specificity and dysregulation in various cancer types, underscoring their potential as diagnostic and prognostic biomarkers.

Understanding the intricate interplay between ncRNAs and cancer will provide multiple opportunities for novel approaches in precision medicine and therapeutics.

We invite submissions on the role of non-coding RNAs (ncRNAs) in cancer to Exploration of Targeted Anti-tumor Therapy.

Keywords: ncRNA; lncRNA; miRNA; circular RNA; eRNAs; targeted therapy; biomarkers; prognostic biomarkers